Cargo size matters when designing lipid nanoparticles for delivery of large gene editors

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 28 Sept, 00:00 UTC

Nature Biotechnology, Published online: 28 September 2026; doi:10.1038/s41587-026-03297-9 Lipid nanoparticles often show reduced performance when delivering the large messenger RNAs that encode gene editors. Screening ionizable lipids with a gene-editor-sized RNA identified LC-1, which forms a…

Sources

• T1Cargo size matters when designing lipid nanoparticles for delivery of large gene editorsNature / Science / Nature Biotechnology28 Sept, 00:00