This cholesterol drug promised to be a game-changer. Why did it flop in the clinic — and is there still hope?

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 03 Nov, 00:00 UTC

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03504-2 Physicians were excited about several therapies that slash levels of lipoprotein(a) — an important cardiovascular risk factor. One major trial failed to show a benefit, and now scientists are scrambling to work out what that…

Sources

• T1This cholesterol drug promised to be a game-changer. Why did it flop in the clinic — and is there still hope?Nature / Science / Nature Biotechnology03 Nov, 00:00