MCT1-dependent mitochondrial lactate import sustains cardiac metabolism

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 28 Oct, 00:00 UTC

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11182-3 In mouse myocardium, glucose oxidation persists in the absence of the mitochondrial pyruvate carrier, with mitochondrial MCT1 importing lactate into mitochondria and LDHB oxidizing it to pyruvate and NADH, sustaining cardiac…

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• T1MCT1-dependent mitochondrial lactate import sustains cardiac metabolismNature / Science / Nature Biotechnology28 Oct, 00:00