T and B cells recognize splicing-derived neutrophil neoantigens in lupus

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 28 Oct, 00:00 UTC

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11219-7 In systemic lupus erythematosus, aberrant splicing in neutrophils generates novel peptides that are presented on MHC I, driving CD4+ and CD8+ T cell activation, clonal expansion and IgG autoantibody responses, establishing…