Human Argonaute 2 is a programmable targeting domain for RNA editing

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 22 Oct, 00:00 UTC

Nature Biotechnology, Published online: 22 October 2026; doi:10.1038/s41587-026-03358-z ALTER is a programmable RNA base editor built entirely from human proteins. By using human AGO2 instead of bacterial CRISPR–Cas proteins, ALTER mitigates a key risk factor for harmful immune responses in…

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• T1Human Argonaute 2 is a programmable targeting domain for RNA editingNature / Science / Nature Biotechnology22 Oct, 00:00