GRP75-dependent SIMPA mediates inter-organellar quality control

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 21 Oct, 00:00 UTC

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and…

Sources

• T1GRP75-dependent SIMPA mediates inter-organellar quality controlNature / Science / Nature Biotechnology21 Oct, 00:00