Persistent neuronal stress signalling underlies Angelman syndrome phenotypes

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 21 Oct, 00:00 UTC

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11165-4 Genetic and proteomic analyses in human neurons and mouse models of Angelman syndrome (AS) show that loss of the ubiquitin ligase UBE3A leads to an overabundance of asparagine synthetase, and that this is linked with many AS…

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• T1Persistent neuronal stress signalling underlies Angelman syndrome phenotypesNature / Science / Nature Biotechnology21 Oct, 00:00