WEE1 opposes APC/CCDH1 activity to promote S phase entry

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 21 Oct, 00:00 UTC

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11188-x Experimental and modelling data indicate that WEE1 promotes re-entry of quiescent cells into the cell cycle, potentially explaining the toxic side effects of WEE1 inhibitors in cancer therapies.

Sources

• T1WEE1 opposes APC/CCDH1 activity to promote S phase entryNature / Science / Nature Biotechnology21 Oct, 00:00