Computational design of metalloproteases

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 14 Oct, 00:00 UTC

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11167-2 RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable proteases with potential applications…