De novo design of cysteine proteases

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 14 Oct, 00:00 UTC

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11143-w De novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.