A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 30 Sept, 00:00 UTC

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11093-3 Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to stress and whose deregulation underlies tumorigenesis in…

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• T1A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activationNature / Science / Nature Biotechnology30 Sept, 00:00