GPCR antagonism via rewiring of receptor trafficking and degradation

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 30 Sept, 00:00 UTC

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11088-0 A strategy for functional G-protein-coupled receptor (GPCR) antagonism through bispecific antibody-mediated endocytosis and lysosomal degradation is reported.

Sources

• T1GPCR antagonism via rewiring of receptor trafficking and degradationNature / Science / Nature Biotechnology30 Sept, 00:00