Human genetics implicates a BACH2–NRF2 axis in fetal haemoglobin activation

T1Covered by 1 source · first reported by Nature / Science / Nature Biotechnology at 30 Sept, 00:00 UTC

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11113-2 BACH2 restrains activation of the fetal-haemoglobin-encoding γ-globin genes, while loss of BACH2 enhances NRF2 chromatin occupancy and promotes the formation of activation foci at the γ-globin genes.

Sources

• T1Human genetics implicates a BACH2–NRF2 axis in fetal haemoglobin activationNature / Science / Nature Biotechnology30 Sept, 00:00